BindingDB BDBM357015 US10214511, Example 19::US10676460, Example 19

BDBM357015 US10214511, Example 19::US10676460, Example 19

SMILES Clc1nc(NCc2ccccn2)c2c(cccc2n1)-c1ccccc1

InChI Key InChIKey=JSYVMXAHYRRFOQ-UHFFFAOYSA-N

Data 50 IC50

Found 1 hit for monomerid = 357015

Cyclin-dependent kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent

BDBM357015(US10214511, Example 19 | US10676460, Example 19)

IC50: 5.00E+4nMAssay Description:The analyses were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and subst...More data for this Ligand-Target Pair

Targets 27▿
- Insulin-like growth factor 1 receptor 4
- Serine/threonine-protein kinase pim-1 4
- Aurora kinase A 3
- Serine/threonine-protein kinase PLK1 2
- Interleukin-1 receptor-associated kinase 4 2
- Tyrosine-protein kinase BTK 2
- Mitogen-activated protein kinase kinase kinase 8 2
- Casein kinase I isoform alpha 2
- Tyrosine-protein kinase JAK1 2
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 2
- Tyrosine-protein kinase JAK3 2
- Tyrosine-protein kinase JAK2 2
- Proto-oncogene tyrosine-protein kinase Src 2
- Non-receptor tyrosine-protein kinase TYK2 2
- Casein kinase II subunit alpha 2
- Casein kinase II subunit alpha' 2
- Cyclin-dependent kinase 5 activator 1 2
- Glycogen synthase kinase-3 beta 2
- Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 1
- Receptor-type tyrosine-protein kinase FLT3 1
- Cyclin-dependent kinase 5 activator 1 [99-307] 1
- Cyclin-dependent kinase 2 1
- Potassium voltage-gated channel subfamily A member 5 1
- Aurora kinase B 1
- Cyclin-dependent kinase 5 1
- Vascular endothelial growth factor receptor 3 1
- Potassium voltage-gated channel subfamily H member 2 1
Publications 3▿
- US Patent US10214511 (2019) 24
- US Patent US10676460 (2020) 24
- ACS Med Chem Lett 7: 831-4 (2016) 2
Institutions 1▿
- Bristol-Myers Squibb 50
Affinity: 50 to 8.0E+4 nM▿
- IC50 50
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1